Table 1.

Biophysical parameters of the two study modelsa

Glucose (mmol/L)HbA1c (%)Systolic BP (mmHg)Weight (g)
AGE infusion
    sham6.1 ± 0.23.1 ± 0.2122 ± 5439 ± 6
    RSA6.2 ± 0.33.1 ± 0.2120 ± 2436 ± 7
    AGE-RSA6.8 ± 0.33.0 ± 0.2119 ± 3452 ± 9b
    AGE-RSA + valsartan6.9 ± 0.33.0 ± 0.2110 ± 4b,c426 ± 10c
Ang II infusion
    vehicle6.4 ± 0.13.0 ± 0.2125 ± 5318 ± 11
    Ang II6.1 ± 0.33.1 ± 0.2175 ± 7b302 ± 9
    Ang II + pyridoxamine6.1 ± 0.33.1 ± 0.2165 ± 9b310 ± 6
  • a Data are shown as mean ± SEM. AGE, advanced glycation end products; RSA, rat serum albumin; Ang II, angiotensin II.

    P < 0.05

  • b versus model control,

  • c versus AGE-RSA.