Table 1.

Urine and serum analyses and body weighta

Wild-Type1α-OHase−/−TRPV5−/−TRPV5−/−/1α-OHase−/−
Urine
Diuresis (ml/24 h)1.8 ± 0.22.3 ± 0.34.4 ± 0.6b1.8 ± 0.5
pH7.6 ± 0.27.9 ± 0.16.1 ± 0.1b7.8 ± 0.2
Serum
1,25(OH)2D3(pmol/L)193 ± 27<6632 ± 63b<6
PTH (pg/ml)44 ± 101444 ± 123b29 ± 62328 ± 212b
Body weight (g)24.6 ± 1.714.1 ± 0.4b21.7 ± 0.812.8 ± 1.1b
  • a Data are presented as means ± SEM. 1α-OHase−/−, 1α-OHase knockout mice; TRPV5−/−, TRPV5 knockout mice; TRPV5−/−/1α-OHase−/−, TRPV5/1α-OHase double knockout mice; PTH, parathyroid hormone. The minimum detection level of the 1,25(OH)2D3 assay was 6 pmol/L.

  • b P < 0.05, significant difference from wild-type mice.