Table 1.

Serum, urinary, and histologic findings in kidneys of 24-wk-old MLRlpr/lpr mice that received injections from 11 to 24 weeks of agea

Saline(n = 9)ODN 2114(n = 10)P
Spleen weight0.80 ± 0.130.56 ± 0.140.01
Lung histologic score1.6 ± 0.50.9 ± 0.70.03
Kidney
    proteinuria (μg/mg creatinine)16.1 ± 5.97.4 ± 1.90.05
    histologic scores
        activity index15.3 ± 3.96.9 ± 2.30.0003
        chronicity index5.1 ± 2.11.1 ± 1.70.002
    cellular response (cells/glomerulus or hpf)
        glomerular
            EHR3+ (cells/glom)0.9 ± 0.30.8 ± 1.30.84
            CD3+ (cells/glom)1.2 ± 1.01.7 ± 0.80.58
            Ki-67+ (cells/glom)5.7 ± 1.62.8 ± 1.20.01
        interstitial
            EHR3+ (cells/hpf)14.4 ± 7.47.0 ± 4.80.03
            CD3+ (cells/hpf)65.7 ± 27.239.1 ± 12.90.02
            Ki-67+ (cells/hpf)12.1 ± 5.67.4 ± 3.20.05
        tubular
            Ki-67+ (cells/hpf)4.8 ± 2.02.8 ± 1.10.04
    humoral response (glomerular deposit score)
        IgG11.5 ± 0.31.1 ± 0.20.047
        IgG2a2.5 ± 0.31.7 ± 0.50.003
  • a Values are means ± SEM from 8 to 10 mice per group.