Table 1.

Changes in liver and renal function (12-wk experiment, protocol 1)a

Control(n = 7)Cirrhosis(n = 10)
Body weight (g)312.0 ± 2.5306.6 ± 11.6
Ascites (ml)Nondetectable17.3 ± 2.27
UO (μl/min)8.5 ± 0.86.7 ± 0.5
PALT, U/L51.4 ± 4.4141.3 ±17.0b
Pbilirubin (μmol/L)2.1 ± 0.114.7 ± 2.1b
Pcr (μmol/L)32.1 ± 2.025.3 ± 0.6c
Ccr (ml/min)1.48 ± 0.091.29 ± 0.15
PNa (mEq/L)137.4 ± 0.8135.5 ± 0.7
PK (mEq/L)5.7 ± 0.35.9 ± 0.2
UNa×UO (mmol)1.45 ± 0.120.96 ± 0.26
Na balance (mmol/d)0.26 ± 0.120.92 ± 0.19c
FENa (%)0.50 ± 0.030.33 ± 0.06c
FEK (%)33.7 ± 2.133.9 ± 2.4
Urine Na/K0.36 ± 0.020.22 ± 0.05c
  • a Values are expressed as mean ± SE. These values are measured at the last day of experiments (12 wk). UO, urine output; PALAT, plasma alanine aminotransferase; Pbilirubin, plasma bilirubin; PNa, plasma sodium; PK, plasma potassium; Pcr, plasma creatinine; Ccr, creatinine clearance; UNa×UO, rate of urinary sodium excretion; Na balance, the difference between dietary sodium intake and urinary sodium excretion in the 24 h; FENa, fractional excretion of sodium into urine; FEK, fractional excretion of potassium into urine; Urine Na/K, urine sodium/potassium ratio.

  • b P < 0.01 versus control.

  • c P < 0.05 versus control.