Table 4.

Changes in liver and renal function (11-wk experiment, protocol 2)a

Control(n = 7)Cirrhosis(n = 11)
Body weight (g)306.4 ± 2.8306.9 ± 7.3
Ascites (ml)Nondetectable7.3 ± 1.6
UO (μl/min)9.1 ± 0.67.8 ± 0.6
PALT (U/L)42.8 ± 2.2185.6 ± 28.4b
Pbilirubin (μmol/L)2.0 ± 0.26.9 ± 1.5b
Pcr (μmol/L)32.3 ± 2.329.2 ± 3.3
Ccr (ml/min)1.47 ± 0.091.40 ± 0.12
PNa (mEq/L)137.8 ± 0.6136.7 ± 0.2
PK (mEq/L)4.4 ± 0.14.7 ± 0.1
UNa×UO (mmol)1.88 ± 0.061.24 ± 0.18c
Na balance (mmol/d)0.02 ± 0.050.52 ± 0.27c
FENa (%)0.66 ± 0.050.49 ± 0.07c
FEK (%)45.3 ± 2.644.0 ± 2.7
Urine Na/K0.45 ± 0.010.34 ± 0.05c
  • a Values are expressed as mean ± SE. These values are measured at the last day of experiments (11 wk).

  • b P < 0.01 versus control.

  • c P < 0.05 versus control.