Table 1.

Pharmacokinetic parameters of liposomes, OX7-IL, and OX7-IL + F(ab′)2a

T1/2 (min)Systemic Volume of Distribution (ml/kg)Blood Clearance (ml/min per kg)AUC0-∞ (dpm/min per μl)
Liposomes210 ± 4270 ± 50.24 ± 0.103944 ± 878
Immunoliposomes25 ± 189 ± 52.46 ± 0.30367 ± 21
Immunoliposomes + F(ab′)2122 ± 2887 ± 70.52 ± 0.201855 ± 580
  • a OX7-IL, OX7-coupled immunoliposomes; T1/2, half-life; AUC0-∞, area under the curve.