Table 1.

Contractility and relaxation indicesa

WTFetuin-A−/−
LVDP (mmHg)105 ± 13118 ± 16
CI (/s)43 ± 1.845 ± 1.8
RI (/s)−32 ± 2.1−26 ± 1.9b
  • a Contractility index (CI) and relaxation index (RI; dP/dtmax and dP/dtmin, respectively, normalized for left ventricular developed pressure [LVDP]) of Langendorff perfused isolated hearts (n = 8 per group).

    Fetuin-knockout mice showed significant impairment of RI (

  • b P < 0.005) whereas other parameters of contractility remained at par with wild-type (WT) mice.