Table 2.

Mortality associated with selected changes in SCra

CriterionUnadjusted OR (95% CI)Age- and Gender-Adjusted OR (95% CI)Multivariable OR (95% CI)bArea under ROC Curve
↑ SCr ≥ 0.3 mg/dl6.9 (5.2 to 9.0)6.6 (5.0 to 8.7)4.1 (3.1 to 5.5)0.84
↑ SCr ≥ 0.5 mg/dl11.1 (8.7 to 14.2)10.6 (8.3 to 13.6)6.5 (5.0 to 8.5)0.86
↑ SCr ≥ 1.0 mg/dl19.9 (15.1 to 26.1)19.0 (14.4 to 25.0)9.7 (7.1 to 13.2)0.84
↑ SCr ≥ 2.0 mg/dl36.4 (24.3 to 54.6)37.7 (25.0 to 56.9)16.4 (10.3 to 26.0)0.83
↑ SCr by 25%4.0 (3.0 to 5.2)3.9 (3.0 to 5.2)2.0 (1.2 to 3.9)0.83
↑ SCr by 50%5.9 (4.6 to 7.5)5.8 (4.6 to 7.5)4.4 (3.4 to 5.7)0.84
↑ SCr by 100%8.9 (6.9 to 11.4)9.2 (7.1 to 11.8)6.5 (4.9 to 8.6)0.84
↑ SCr by 50% to a minimum peak of 2.0 mg/dl16.9 (12.8 to 22.3)15.9 (12.0 to 21.0)7.9 (5.8 to 10.9)0.84
↑ SCr ≥ 0.5 mg/dl with baseline SCr < 2.0 mg/dl or ↑ SCr ≥ 1.0 mg/dl with baseline SCr ≥ 2.0 and < 5.0 mg/dl11.0 (8.6 to 14.0)10.5 (8.2 to 13.4)6.5 (5.0 to 8.5)0.86
  • a n = 2892, 1236, 351, 105, 4060, 1967, 714, 352, and 1160 for respective acute kidney injury (AKI) criteria from denominator sample n = 9205. Results are relative to those without the change indicated. Multivariable analyses were adjusted for age, gender, DRG weight, chronic kidney disease status, and International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for respiratory, gastrointestinal, malignant, and infectious diseases. Area under ROC curve for multivariable model. SCr, serum creatinine; OR, odds ratio; CI, confidence interval; ROC, receiver operating characteristic.

  • b Corresponding estimates of the multivariable relative risk (using the method of Zhang and Yu) 4.0, 6.0, 8.3, 11.8, 2.0, 4.2, 5.9, 6.9, and 6.0 from column top to bottom.