Table 2.

Removal of urea and protein-bound solutes during hemodialysis

Urea NitrogenPCSIndican
Plasma level pretreatment, mg/dl57 ± 104.3 ± 1.12.7 ± 1.3
Plasma level posttreatment, mg/dl18 ± 4a3.2 ± 1.2a1.9 ± 0.8a
Plasma level 30 min posttreatment, mg/dl22 ± 5b3.1 ± 1.01.9 ± 0.9
Reduction ratio0.69 ± 0.050.27 ± 0.110.30 ± 0.07
Unbound fraction pretreatment, %7.8 ± 1.37.6 ± 1.5
Unbound fraction posttreatment, %4.7 ± 1.4a5.4 ± 2.2a
Unbound fraction 30 min posttreatment, %5.3 ± 1.96.6 ± 3.0
Solute removed during dialysis, mg18.0 ± 2.1 × 103161 ± 62119 ± 59
Volume of distribution, L37 ± 715 ± 714 ± 3
Measured clearance, ml/min260 ± 2020 ± 425 ± 5
Modeled clearance, ml/min302 ± 11c29 ± 3c31 ± 8c
  • Values are mean ± SD. Values for indican and PCS in each case were not significantly different from each other but were significantly lower (P < 0.05, ANOVA and LSD) than values for urea nitrogen.

  • a P < 0.05 vs value pretreatment.

  • b P < 0.05 value 30 min posttreatment vs value posttreatment.

  • c P < 0.05 modeled vs measured.