Table 3.

Phenotypic characterization of male C57Bl6/J TK−/− and WT littermates on NCa diet (0.9% wt/wt Ca)

0.9% wt/wt Ca
WT (n = 15)TK−/− (n = 14)
Weight (g)24.9 ± 0.424.0 ± 0.5
Food intake (g/24 h)4.16 ± 0.154.18 ± 0.25
Urine values
    volume (ml/24 h)1.27 ± 0.171.71 ± 0.28
    creatinine excretion (μmol/24 h)4.08 ± 0.184.60 ± 0.29
    Ca excretion (μmol/24 h)1.56 ± 0.162.54 ± 0.44a
    UCa/UCr (mmol/mmol)0.38 ± 0.030.52 ± 0.08
    Na excretion (μmol/24 h)322 ± 19311 ± 26
    UNa/UCr (mmol/mmol)78.9 ± 2.767.3 ± 3.2a
    UCa/UNa (μmol/mmol)5.0 ± 0.48.7 ± 1.5a
    UPi/UCr (mmol/mmol)49.9 ± 2.344.1 ± 2.3
    UcAMP/UCr (μmol/mmol)7.18 ± 0.356.78 ± 0.45
    UDPyr/UCr (nmol/mmol)13.41 ± 1.0311.63 ± 0.58
Plasma values
    total Ca (mM)2.20 ± 0.082.03 ± 0.1
    protein (g/L)36.7 ± 0.636.2 ± 0.7
    creatinine (μM)16.6 ± 1.413.5 ± 1.3
    1,25-dihydroxy vitamin D (pmol/L)120 ± 12203 ± 25b
    PTH (pg/ml)15.1 ± 1.418.3 ± 6.1
    Pi (mM)3.06 ± 0.182.99 ± 0.08
  • a P < 0.05 versus WT.

  • b P < 0.01 versus WT.\