Table 2.

Association of CysC and SCr with MRI-defined SBI, by gendera

Renal Function MarkerAdjustment VariablesOR of SBI (per 1-SD Decrementb; 95% CI)
All (n = 2784)Women (n = 1684)Men (n = 1100)
1/CysCUnadjusted1.27 (1.17 to 1.38)1.24 (1.11 to 1.38)1.33 (1.16 to 1.53)
Partially adjustedb1.24 (1.13 to 1.36)1.19 (1.06 to 1.34)1.31 (1.13 to 1.52)
Fully adjustedc1.20 (1.09 to 1.32)1.16 (1.02 to 1.31)1.25 (1.08 to 1.46)
1/SCrUnadjusted1.10 (1.02 to 1.20)e1.07 (0.95 to 1.19)e1.33 (1.11 to 1.60)e
Partially adjustedb1.10 (0.99 to 1.21)e1.03 (0.92 to 1.16)e1.28 (1.06 to 1.55)e
Fully adjustedc1.08 (0.98 to 1.19)e1.02 (0.91 to 1.15)1.23 (1.01 to 1.50)
  • a OR, odds ratio; CI, confidence interval.

  • b Equivalent to a relative increase in CysC or SCr.

  • c Adjusted for age, gender, race, weight, and height.

  • d Adjusted for all variables above in addition to diabetes, smoking, SBP and DBP, use of antihypertensive medications, and aspirin use.

  • e A quadratic or U-shaped relationship between 1/SCr and SBI is suggested (P < 0.05 for test of quadratic term).