Table 2.

Recipient and donor factors associated with allograft failure (univariate analysis)a

VariableRR and 95% CI
Recipient race
    African-American race versus non–African-American race1.47 (1.43–1.51)
Site of pretransplant care and transplant setting
    VA user (inclusive of VA dialysis and VA     transplant and VA dialysis and non-VA     transplant) versus non-VA user (non-VA     transplant and non-VA dialysis)1.40 (1.30–1.50)
Recipient age (per 10-yr increase)1.11 (1.09–1.12)
Recipient age2 (per 10-yr increase)1.01 (1.00–1.01)
Recipient female gender0.98 (0.96–1.00)
Comorbidities (present versus absent)
    treated COPD1.13 (1.11–1.15)
    treated hypertension1.18 (1.16–1.20)
    cerebrovascular disease1.14 (1.13–1.16)
    cardiovascular disease1.14 (1.13–1.16)
    peripheral vascular disease1.14 (1.13–1.15)
    diabetes1.17 (1.15–1.19)
Recipient BSA
    <1.60.94 (0.91–0.98)
    1.6–1.80.94 (0.91–0.98)
    1.8–2.01.00 (referent)
    2.0–2.21.06 (1.02–1.20)
    >2.21.15 (1.09–1.21)
Duration on dialysis pretransplant (per 1-yr increase)1.04 (1.04–1.05)
Dialysis modality at ESRD initiation
    peritoneal dialysis versus hemodialysis0.91 (0.88–0.93)
Dialysis modality pretransplantation
    peritoneal dialysis versus hemodialysis0.92 (0.85–1.00)
Recipient socioeconomic factors
    functional status (independent in activities of daily     living versus not)0.77 (0.74–0.80)
    employed versus unemployed0.96 (0.95–0.98)
    college educated versus not0.85 (0.82–0.88)
HLA mismatch
    00.74 (0.70–0.77)
    10.93 (0.87–0.98)
    20.95 (0.91–0.99)
    31.00 (referent)
    41.12 (1.08–1.16)
    51.16 (1.12–1.20)
    61.20 (1.15–1.27)
PRA
    peak PRA >50%1.23 (1.18–1.29)
    most recent PRA >50%1.26 (1.18–1.34)
Cold ischemia time
    <1 h1.00 (referent)
    1–12 h1.23 (1.16–1.30)
    13–24 h1.52 (1.46–1.60)
    >25 h1.73 (1.64–1.83)
Transplant era
    1991–19931.00 (referent)
    1993–19950.94 (0.91–0.97)
    1995–19970.77 (0.74–0.80)
    1997–20000.75 (0.73–0.79)
Living donor versus cadaver donor0.66 (0.64–0.68)
Donor race
    Caucasian1.00 (referent)
    African American1.28 (1.24–1.32)
    Other0.87 (0.81–0.93)
Donor age (per 10-yr increase)1.10 (1.09–1.11)
Donor female gender1.06 (1.04–1.09)
Mechanism of donor death (vascular [cardio- and cerebrovascular] versus nonvascular)1.44 (1.41–1.47)
  • a RR, relative risk; CI, confidence interval.