Table 2.

Characteristicsa of ARIC Study participants with CKD who did and did not develop a major CHD eventb during 10.5 yr of follow-up

Risk FactorNo CHD (n = 699)Incident CHD during Follow-upb (n = 108)P Value
Age (yr)55.858.0<0.001
Men (%)29.554.7<0.001
Black (%)9.822.5<0.001
Traditional risk factors
    current smoking (%)
    physically active (%)26.421.20.278
    hypertension (%)28.429.80.023
    systolic BP (mmHg)31.841.20.075
    BMI (kg/m2)124.3130.40.007
    obesity (BMI ≥30 kg/m2)55.370.10.013
    glucose (mg/dl)118.9150.0<0.001
    diabetes (%)17.236.3<0.001
    total cholesterol (mg/dl)218.8239.9<0.001
    HDL cholesterol (mg/dl)
    log triglycerides, log (mg/dl)4.845.05<0.001
Nontraditional risk factors
    waist circumference99.0102.90.009
    log Lp(a), log (mg/L)4.124.310.125
    apolipoprotein-A1 (mg/dl)129.8127.30.408
    apolipoprotein-B (mg/dl)98.2108.80.003
    anemia (%)
    leukocyte count (109 cells/L)6.276.84<0.001
    serum albumin (mg/dl)3.843.750.005
    fibrinogen (mg/dl)317.9350.8<0.001
  • a Prevalence and levels reflect the visit at which CKD was first noted (visit 1 for 391 participants and visit 2 for 416 participants) and are standardized for all variables except age, gender, and race to the ARIC population with CKD (age, 56.1; gender, 33.0% male; and 21.8% black race).

  • b CHD events include myocardial infarction incidence, fatal CHD, or coronary revascularization. CKD, chronic kidney disease; CHD, coronary heart disease.