Relative riska (95% CI) of a major CHD eventb among ARIC study participants associated with quartile of CHD risk factor by level of kidney function (estimated GFR ≥90, 60 to 89, and 15 to 59 ml/min per 1.73 m2)
| Quartile | P Value for Trend | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| Systolic BP (mmHg) | <111 | 112–122 | 123–138 | ≥139 | |
| GFR ≥90 | 1.00 | 1.26 (0.89–1.78) | 1.93 (1.41–2.63) | 2.21 (1.56–3.13) | <0.001 |
| 60–89 | 1.00 | 1.07 (0.87–1.32) | 1.73 (1.44–2.07) | 2.39 (1.96–2.91) | <0.001 |
| 15–59 | 1.00 | 1.52 (0.82–2.83) | 1.08 (0.57–2.05) | 2.37 (1.33–4.21) | 0.011 |
| BMI (kg/m2) | <24.7 | 24.7–27.5 | 27.6–31.4 | ≥31.4 | |
| GFR ≥90 | 1.00 | 1.32 (0.98–1.79) | 1.67 (1.23–2.26) | 1.38 (0.99–1.92) | 0.008 |
| 60–89 | 1.00 | 1.17 (0.97–1.41) | 1.36 (1.13–1.65) | 1.62 (1.32–1.98) | <0.001 |
| 15–59 | 1.00 | 1.14 (0.60–2.17) | 1.33 (0.72–2.45) | 1.78 (0.97–3.25) | 0.052 |
| Total Cholesterol (mg/dl) | <190 | 191–217 | 218–244 | ≥245 | |
| GFR ≥90 | 1.00 | 1.44 (1.04–1.99) | 1.73 (1.24–2.42) | 2.04 (1.50–2.79) | <0.001 |
| 60–89 | 1.00 | 1.19 (0.97–1.45) | 1.50 (1.22–1.84) | 2.22 (1.84–2.67) | <0.001 |
| 15–59 | 1.00 | 1.29 (0.68–2.45) | 1.98 (1.08–3.61) | 2.25 (1.27–3.99) | 0.002 |
| HDL cholesterol (mg/dl) | <40 | 40–49 | 50–61 | ≥62 | |
| GFR ≥90 | 1.00 | 0.77 (0.59–1.00) | 0.44 (0.32–0.61) | 0.23 (0.16–0.35) | <0.001 |
| 60–89 | 1.00 | 0.58 (0.50–0.69) | 0.53 (0.44–0.64) | 0.27 (0.21–0.35) | <0.001 |
| 15–59 | 1.00 | 0.72 (0.43–1.23) | 0.73 (0.42–1.30) | 0.62 (0.34–1.14) | 0.127 |
| Triglycerides (mg/dl) | <87 | 87–124 | 125–181 | ≥182 | |
| GFR ≥90 | 1.00 | 1.53 (1.12–2.08) | 1.77 (1.29–2.44) | 2.51 (1.85–3.42) | <0.001 |
| 60–89 | 1.00 | 1.47 (1.20–1.80) | 1.82 (1.49–2.22) | 2.47 (2.02–3.03) | <0.001 |
| 15–59 | 1.00 | 1.84 (0.92–3.67) | 1.74 (0.91–3.29) | 2.73 (1.46–5.10) | 0.002 |
| Waist circumference (cm) | <90 | 91–99 | 100–108 | ≥109 | |
| GFR ≥90 | 1.00 | 1.51 (1.09–2.07) | 1.70 (1.23–2.35) | 1.81 (1.29–2.54) | <0.001 |
| 60–89 | 1.00 | 1.35 (1.09–1.66) | 1.45 (1.18–1.79) | 1.98 (1.59–2.46) | <0.001 |
| 15–59 | 1.00 | 0.82 (0.40–1.65) | 1.26 (0.67–2.35) | 1.77 (0.97–3.23) | 0.013 |
| Leukocyte count (109 cells/L) | <4.9 | 5.0–6.0 | 6.1–7.2 | ≥7.3 | |
| GFR ≥90 | 1.00 | 1.55 (1.10–2.19) | 1.66 (1.15–3.38) | 2.67 (1.93–3.68) | <0.001 |
| 60–89 | 1.00 | 1.16 (0.95–1.43) | 1.66 (1.35–2.05) | 2.42 (1.99–2.95) | <0.001 |
| 15–59 | 1.00 | 1.84 (0.94–3.63) | 2.09 (1.04–4.21) | 3.31 (1.74–6.32) | <0.001 |
| Serum albumin (mg/dl) | |||||
| GFR ≥90 | 1.00 | 0.62 (0.45–0.84) | 0.67 (0.50–0.89) | 0.46 (0.33–0.65) | <0.001 |
| 60–89 | 1.00 | 0.68 (0.55–0.85) | 0.81 (0.67–1.00) | 0.75 (0.61–0.93) | 0.147 |
| 15–59 | 1.00 | 0.57 (0.33–0.99) | 0.52 (0.29–0.92) | 0.38 (0.20–0.70) | 0.003 |
| Fibrinogen (mg/dl) | <270 | 271–310 | 311–358 | ≥359 | |
| GFR ≥90 | 1.00 | 1.32 (0.95–1.83) | 1.80 (1.31–2.48) | 2.77 (2.02–3.80) | <0.001 |
| 60–89 | 1.00 | 1.52 (1.27–1.82) | 2.06 (1.71–2.48) | 2.54 (2.08–3.09) | <0.001 |
| 15–59 | 1.00 | 1.46 (0.67–3.20) | 3.68 (1.80–7.52) | 4.27 (2.09–8.71) | <0.001 |