Table 4.

Relative riska (95% CI) of a major CHD eventb among ARIC study participants associated with quartile of CHD risk factor by level of kidney function (estimated GFR ≥90, 60 to 89, and 15 to 59 ml/min per 1.73 m2)

QuartileP Value for Trend
1234
Systolic BP (mmHg)<111112–122123–138≥139
    GFR ≥901.001.26 (0.89–1.78)1.93 (1.41–2.63)2.21 (1.56–3.13)<0.001
    60–891.001.07 (0.87–1.32)1.73 (1.44–2.07)2.39 (1.96–2.91)<0.001
    15–591.001.52 (0.82–2.83)1.08 (0.57–2.05)2.37 (1.33–4.21)0.011
BMI (kg/m2)<24.724.7–27.527.6–31.4≥31.4
    GFR ≥901.001.32 (0.98–1.79)1.67 (1.23–2.26)1.38 (0.99–1.92)0.008
    60–891.001.17 (0.97–1.41)1.36 (1.13–1.65)1.62 (1.32–1.98)<0.001
    15–591.001.14 (0.60–2.17)1.33 (0.72–2.45)1.78 (0.97–3.25)0.052
Total Cholesterol (mg/dl)<190191–217218–244≥245
    GFR ≥901.001.44 (1.04–1.99)1.73 (1.24–2.42)2.04 (1.50–2.79)<0.001
    60–891.001.19 (0.97–1.45)1.50 (1.22–1.84)2.22 (1.84–2.67)<0.001
    15–591.001.29 (0.68–2.45)1.98 (1.08–3.61)2.25 (1.27–3.99)0.002
HDL cholesterol (mg/dl)<4040–4950–61≥62
    GFR ≥901.000.77 (0.59–1.00)0.44 (0.32–0.61)0.23 (0.16–0.35)<0.001
    60–891.000.58 (0.50–0.69)0.53 (0.44–0.64)0.27 (0.21–0.35)<0.001
    15–591.000.72 (0.43–1.23)0.73 (0.42–1.30)0.62 (0.34–1.14)0.127
Triglycerides (mg/dl)<8787–124125–181≥182
    GFR ≥901.001.53 (1.12–2.08)1.77 (1.29–2.44)2.51 (1.85–3.42)<0.001
    60–891.001.47 (1.20–1.80)1.82 (1.49–2.22)2.47 (2.02–3.03)<0.001
    15–591.001.84 (0.92–3.67)1.74 (0.91–3.29)2.73 (1.46–5.10)0.002
Waist circumference (cm)<9091–99100–108≥109
    GFR ≥901.001.51 (1.09–2.07)1.70 (1.23–2.35)1.81 (1.29–2.54)<0.001
    60–891.001.35 (1.09–1.66)1.45 (1.18–1.79)1.98 (1.59–2.46)<0.001
    15–591.000.82 (0.40–1.65)1.26 (0.67–2.35)1.77 (0.97–3.23)0.013
Leukocyte count (109 cells/L)<4.95.0–6.06.1–7.2≥7.3
    GFR ≥901.001.55 (1.10–2.19)1.66 (1.15–3.38)2.67 (1.93–3.68)<0.001
    60–891.001.16 (0.95–1.43)1.66 (1.35–2.05)2.42 (1.99–2.95)<0.001
    15–591.001.84 (0.94–3.63)2.09 (1.04–4.21)3.31 (1.74–6.32)<0.001
Serum albumin (mg/dl)
    GFR ≥901.000.62 (0.45–0.84)0.67 (0.50–0.89)0.46 (0.33–0.65)<0.001
    60–891.000.68 (0.55–0.85)0.81 (0.67–1.00)0.75 (0.61–0.93)0.147
    15–591.000.57 (0.33–0.99)0.52 (0.29–0.92)0.38 (0.20–0.70)0.003
Fibrinogen (mg/dl)<270271–310311–358≥359
    GFR ≥901.001.32 (0.95–1.83)1.80 (1.31–2.48)2.77 (2.02–3.80)<0.001
    60–891.001.52 (1.27–1.82)2.06 (1.71–2.48)2.54 (2.08–3.09)<0.001
    15–591.001.46 (0.67–3.20)3.68 (1.80–7.52)4.27 (2.09–8.71)<0.001
  • a Adjusted for age, race, gender, and ARIC field center.

  • b Myocardial infarction incidence, fatal coronary heart disease, or coronary revascularization.