Table 3.

Adjusted hazards ratios (with 95% CI) for incident events in 2000 to 2001a

ASVDPCHFPRRTPDeathP
Non-diabetes/non-CKD1 (reference)111
Diabetes/non-CKD1.30 (1.29–1.31)<0.00011.44 (1.42–1.45)<0.00012.52 (2.24–2.83)<0.00011.21 (1.19–1.22)<0.0001
Non-diabetes/CKD1.16 (1.14–1.19)<0.00011.28 (1.25–1.31)<0.000123.1 (20.6–26.0)<0.00011.38 (1.34–1.41)<0.0001
Diabetes/CKD1.41 (1.37–1.44)<0.00011.79 (1.75–1.83)<0.000138.9 (34.7–43.6)<0.00011.56 (1.52–1.61)<0.0001
Age on December 31, 1999 (yr)
    67–691111
    70–741.23 (1.22–1.25)<0.00011.23 (1.20–1.25)<0.00010.91 (0.81–1.02)0.09011.30 (1.27–1.34)<0.0001
    75–791.53 (1.51–1.55)<0.00011.56 (1.53–1.59)<0.00010.80 (0.71–0.90)0.00021.87 (1.83–1.92)<0.0001
    ≥802.01 (1.99–2.04)<0.00012.31 (2.27–2.35)<0.00010.60 (0.53–0.68)<0.00014.00 (3.91–4.10)<0.0001
Gender
    male1.10 (1.09–1.11)<0.00011.12 (1.11–1.13)<0.00011.47 (1.36–1.59)<0.00011.22 (1.21–1.24)<0.0001
    female1111
Race
    white1111
    black1.06 (1.05–1.07)<0.00011.05 (1.04–1.07)<0.00012.09 (1.90–2.29)<0.00011.10 (1.08–1.13)<0.0001
    other0.89 (0.87–0.91)<0.00010.89 (0.87–0.91)<0.00011.28 (1.10–1.51)0.00210.88 (0.85–0.91)<0.0001
Total hospital days, 1998 to 1999
    none11<0.000111
    1–41.04 (1.03–1.05)<0.00011.15 (1.14–1.17)<0.00010.92 (0.82–1.03)0.15931.22 (1.20–1.24)<0.0001
    5–91.02 (1.01–1.03)0.00091.12 (1.11–1.14)<0.00010.81 (0.71–0.91)0.00061.47 (1.44–1.50)<0.0001
    10–191.03 (1.02–1.04)<0.00011.15 (1.13–1.17)<0.00010.74 (0.64–0.84)<0.00011.67 (1.64–1.71)<0.0001
    ≥201.21 (1.19–1.23)<0.00011.21 (1.19–1.23)<0.00010.52 (0.45–0.60)<0.00012.01 (1.97–2.06)<0.0001
Comorbidity
    ASVD4.89 (4.85–4.93)<0.00011.24 (1.23–1.25)<0.00011.03 (0.95–1.12)0.48191.46 (1.44–1.48)<0.0001
    anemia1.09 (1.08–1.10)<0.00011.11 (1.10–1.12)<0.00012.42 (2.22–2.64)<0.00011.29 (1.28–1.31)<0.0001
    CHF1.18 (1.17–1.19)<0.00017.99 (7.91–8.08)<0.00011.85 (1.69–2.02)<0.00011.79 (1.77–1.82)<0.0001
    cancer0.99 (0.98–1.00)0.01030.97 (0.96–0.98)<0.00010.99 (0.91–1.08)0.82021.27 (1.25–1.28)<0.0001
    COPD1.14 (1.13–1.15)<0.00011.37 (1.35–1.38)<0.00010.80 (0.73–0.88)<0.00011.41 (1.39–1.43)<0.0001
    gastrointestinal bleeding1.06 (1.04–1.07)<0.00011.04 (1.02–1.06)<0.00010.94 (0.84–1.06)0.29491.03 (1.01–1.05)0.0004
    liver disease1.03 (1.00–1.07)0.06231.10 (1.06–1.14)<0.00010.55 (0.39–0.76)0.00031.40 (1.34–1.46)<0.0001
    hypertension1.22 (1.21–1.23)<0.00011.20 (1.18–1.21)<0.00011.84 (1.65–2.05)<0.00010.78 (0.77–0.79)<0.0001
  • a Using Cox regression. The exploratory variables were diabetes/CKD group, age, gender, race, hospital days in 1998 to 1999, ASVD, anemia, CHF, cancer, gastrointestinal bleeding, liver disease, and hypertension. The reference categories were absence of diabetes and CKD, age 67 to 69 yr, female gender, white race, no days in hospital in 1998 to 1999, and absence of comorbid conditions.