Table 1.

Genetic linkage data for the study familiesa

Family No.Family SizeGenetic Evidence of PKD1 Linkage
AffectedbUnaffectedLOD Score (PKD1)cLOD Score (PKD2)d
1631.8<−2
2832.1<−2
3641.93<−2
4551.5<−2
5531.2−0.74
6852.4<−2
7440.99−1.06
8430.75−0.66
9451.05−1.35
10541.15−0.66
111184.8<−2
121063.45<−2
13631.15<−2
14430.75−1.26
15631.2−0.89
16631.2<−2
171063.6<−2
18430.75−0.90
19641.45<−2
20430.75−1.68
21540.99−0.23
22530.99−0.76
23731.85<−2
24641.5<−2
25420.5−1.72
26430.75−0.81
27631.15<−2
28721.35<−2
29520.99−0.49
30450.99<−2
311243.3<−2
32530.9−1.27
33731.85<−2
341042.75<−2
35951.85<−2
361173.6<−2
3740e86.6<−2
38641.25<−2
39531.93<−2
40963.44<−2
41631.79<−2
42641.95<−2
43932.17<−2
44631.78<−2
45531.15−0.81
461053.16<−2
47842.93<−2
48721.62−1.29
49631.15−0.56
50651.48−0.48
51963.43<−2
52631.12−0.23
53831.68<−2
54430.9−0.49
55440.99−0.56
56932.35<−2
57440.99−1.37
58541.36−0.99
59852.33<−2
60340.99−1.27
611133.25<−2
62431.15−0.56
63942.86<−2
64731.51<−2
651543.65<−2
66942.75<−2
  • a LOD, logarithm of odds.

  • b Genotyped individuals without clinical and laboratory data were excluded from the heritability study.

  • c Maximal two-point linkage score from PKD1 simple-sequence repeat (SSR) markers.

  • d Minimal two-point linkage score from PKD2 SSR markers.

  • e The LOD scores presented here were calculated base on 26 affected individuals; the disease status in the remaining at-risk individuals was determined by restriction analysis of PKD1 mutation (IVS39-25del 72bp; FS3755→3798X).