Table 3.

Univariate and multivariate determinants of renal failurea

UnivariateMultivariate
Hazard Ratio (95% CI)PHazard Ratio (95% CI)P
Onset
    CrCl (ml/min per 1.73 m2)0.97 (0.96–0.99)<0.0010.97 (0.95–0.98)<0.001
    BMIb
        low0.73 (0.17–3.05)NS1.12 (0.25–5.06)NS
        normal11
        high0.39 (0.21–0.71)0.0020.35 (0.19–0.65)<0.001
    age (yr)1.02 (1.01–1.04)0.0021.01 (0.98–1.07)NS
Follow-up
    MAP (mmHg)1.04 (1.01–1.06)0.0091.02 (0.98–1.07)NS
    remission
        NR11
        PR0.27 (0.16–0.45)<0.0010.48 (0.24–0.96)c0.04
        CR0.07 (0.02–0.21)<0.0010.23 (0.07–0.77)c0.02
    ACEi or ARB therapy0.43 (0.27–0.67)<0.0010.85 (0.46–1.57)cNS
  • a Gender, ethnicity, proteinuria, and MAP at onset as well as immunosuppressive therapy were not predictive of renal survival by univariate analysis. CI, confidence interval.

  • b BMI divided into three categories low (BMI <20), normal (BMI 20 to 27), and high (BMI > 27).

  • c Expressed as a time-dependent variable. For PR and CR, the multivariate analysis used clearance at time of remission.