Table 1.

Baseline characteristics within 90 days of initiating hemodialysis according to injectable vitamin D treatmenta

CharacteristicVitamin D (n = 37,173)No Vitamin D (n = 13,864)P Value
Age (yr)6163<0.01
Gender (% male)5254<0.01
Race (%)<0.01
    white5572
    black3921
    other66
Diabetes (%)53520.80
Hemoglobin A1C (%)b6.896.950.30
Primary cause of renal failure (%)<0.01
    diabetes3636
    hypertension3833
    glomerulonephritis1214
    other1417
Previous peritoneal dialysis (%)0.831.000.03
Previous renal transplant (%)0.380.300.21
Vascular access (%)<0.01
    fistula1917
    graft4338
    catheter3238
    unknown67
Body mass index (kg/m2)2827<0.01
Systolic BP (mmHg)151148<0.01
Diastolic BP (mmHg)7875<0.01
Albumin (g/dl)3.6 ± 0.53.5 ± 0.5<0.01
Calcium (mg/dl)8.6 ± 0.78.7 ± 0.7<0.01
Phosphorus (mg/dl)5.3 ± 1.45.3 ± 1.6<0.01
Calcium × phosphorus (product)46 ± 1246 ± 13<0.01
Intact parathyroid hormone (pg/ml)354 ± 336179 ± 217<0.01
Dialysate calcium (mEq/L)2.71 ± 0.392.80 ± 0.43<0.01
Alkaline phosphatase (U/L)122 ± 85117 ± 89<0.01
Total cholesterol (mg/dl)1771750.01
LDL (mg/dl)b102980.02
Hemoglobin (g/dl)10.3 ± 1.410.3 ± 1.3<0.01
White blood cell count (per mm3)7.5 ± 2.88.0 ± 3.0<0.01
Creatinine (mg/dl)7.4 ± 2.86.9 ± 2.8<0.01
URRc (%)66 ± 965 ± 9<0.01
  • a Baseline laboratory values represent the mean value over the 3 mo before time = 0 (90 days after initiating hemodialysis) for the no vitamin D group and the 3 mo before initiating vitamin D therapy in the vitamin D group. To convert calcium to mmol/L, multiply by 0.25; phosphorus to mmol/L, multiply by 0.32; total cholesterol and LDL to mmol/L, multiply by 0.025; creatinine to μmol/L, multiply by 88.4. URR, urea reduction ratio.

  • b Hemoglobin A1C data available in 8057 patients; LDL data available in 3982 patients.

  • c Measure of dialysis adequacy calculated as 100 × [1 − (postdialysis BUN/predialysis BUN)]. BUN, blood urea nitrogen.