Table 1.

Basic clinical, anthropometric, BP, and biochemical characteristics of patients and control subjectsa

ControlsCKDDialysisRtx
n270553734
% male49595949
Age (yr)14.2 ± 2.615.3 ± 2.614.3 ± 3.015.0 ± 2.7
Height SDS−0.11 ± 1.04c,d,e−0.72 ± 1.18b,d,e−2.76 ± 1.71b,c,e−2.22 ± 1.47b,c,d
BMI SDS0.40 ± 1.1c,d,e−0.32 ± 1.33b,d−0.6 ± 0.9b,c−0.06 ± 1.19b
Time in predialytic CKD (mo)86 ± 6363 ± 4367 ± 60
Cumulative time on dialysis (mo)26 ± 3222 ± 26
Time since transplant (mo)33 ± 38
Systolic BP (mmHg)113 ± 12c,d,e120 ± 16b,d129 ± 15b,c125 ± 13b
Diastolic BP (mmHg)59 ± 6d,e61 ± 13d,e71 ± 15b,c,e67 ± 10b,c,d
No. of antihypertensive drugs0c,d,e1.6 ± 1.3b1.4 ± 1.4b1.4 ± 0.9b
Serum creatinine (mg/dl)0.8 ± 0.1c,d2.7 ± 2.4b,d,e8.6 ± 2.0b,c,e1.5 ± 0.9c,d
GFR (ml/min per 1.73 m2)102 ± 7c,d,e51 ± 31b,d,e<10b,c,e73 ± 31b,c,d
Triglycerides69 ± 37b,c,e139 ± 75b,d,e178 ± 103b,c188 ± 141b,c
Total cholesterol170 ± 37d,e179 ± 33d,e211 ± 58b,c204 ± 46b,c
LDL cholesterol104 ± 32d122 ± 38145 ± 44b,e112 ± 36d
HDL cholesterol51 ± 1247 ± 953 ± 1456 ± 15
Apolipoprotein A1.29 ± 0.231.26 ± 0.291.48 ± 0.311.53 ± 0.29
Apolipoprotein B0.79 ± 0.25d,e0.97 ± 0.26d,e1.39 ± 0.52b,c1.22 ± 0.42b,c
Homocysteine11.1 ± 3.112.7 ± 3.014.3 ± 6.513.8 ± 6.5
CRP (pM)ND5.1 ± 9.12.1 ± 2.12.2 ± 2.7
Current albumin (g/L)ND42.5 ± 4.341 ± 2.142.9 ± 5.6
Time-integrated mean albumin (g/L)42.6 ± 3.638.8 ± 3.441.2 ± 5.1
Current calcium (mM)ND2.36 ± 0.122.43 ± 0.192.38 ± 0.16
Current phosphate (mM)ND1.37 ± 0.29d1.62 ± 0.52c,e1.25 ± 0.31d
Current Ca × P product (mM)ND3.22 ± 0.67d3.89 ± 1.17c,e2.97 ± 0.72d
Current PTH (pM)ND9.9 ± 9.4d27 ± 37c,e12.8 ± 15.4d
Time-integrated mean Ca (mM)2.31 ± 0.182.43 ± 0.192.38 ± 0.16
Time-integrated mean P (mM)1.37 ± 0.29d1.62 ± 0.52c,e1.25 ± 0.31d
Time-integrated mean Ca × P (mM2)3.65 ± 0.35d4.3 ± 0.54c,e3.69 ± 0.60d
Cumulative episodes of Ca × P >4.5 mM20.26 ± 0.570.84 ± 0.990.60 ± 0.78
Time-integrated mean PTH (mM)19.6 ± 15.8d38 ± 28c,e21 ± 17d
Cumulative calcitriol intake (μg/kg)36 ± 55d242 ± 359c,e88 ± 126d
Cumulative P binder intake (g/kg)0.3 ± 0.8d157 ± 189c85 ± 112c
  • a Data are given as mean ± SD. Superscript letters denote statistical significant differences at 5% error level between groups:

  • b significant difference from control group,

  • c from CKD,

  • d from dialysis and

  • e from Rtx group.

  • CKD, chronic kidney disease; Rtx, renal transplantation; SDS, SD score; BMI, body mass index; CRP, C-reactive protein; PTH, parathyroid hormone; ND, not determined.