Table 1.

Animal characteristics in control and diabetic rats that were treated with ruboxistaurina

ControlControl + RuboxistaurinDiabeticDiabetic + Ruboxistaurin
Body wt (g)555 ± 21521 ± 16486 ± 12b481 ± 12b
Kidney wt (g)2.31 ± 0.122.29 ± 0.152.92 ± 0.09b2.73 ± 0.13b
Plasma glucose (mM)5.7 ± 0.55.2 ± 0.224.7 ± 2.4c26.9 ± 1.1c
Hemoglobin A1c (%)3.4 ± 0.23.4 ± 0.210.5 ± 0.6b10.4 ± 0.5b
Plasma creatinine (mM)0.054 ± 0.0050.051 ± 0.0020.070 ± 0.004b0.060 ± 0.003
Albuminuria (mg/d)0.15 x/÷ 0.100.11 x/÷ 0.104.32 x/÷ 0.27b1.10 x/÷ 0.11b,d
Systolic BP (mmHg)204 ± 18202 ± 12221 ± 21217 ± 16
  • a Data are expressed as mean ± SEM. Albuminuria is expressed as geometric means ÷ tolerance factors.

  • b P < 0.05 versus control.

  • c P < 0.01 versus control.

  • d P < 0.05 versus untreated diabetic rats.