Table 2.

Hazards ratiosa (and 95% confidence intervals) for cardiovascular events and death

Cardiovascular Eventb(11,272/14,598c; 77.2%)Death(11,730/14,829; 79.1%)
Calcium quintiles (mg/dl)
    ≤8.71.001.00
    8.8 to 9.21.03 (0.97 to 1.09)1.07 (1.01 to 1.14)d
    9.3 to 9.61.04 (0.97 to 1.10)1.05 (0.99 to 1.12)
    9.7 to 10.21.03 (0.97 to 1.10)1.11 (1.04 to 1.18)d
    >10.21.08 (1.01 to 1.15)d1.14 (1.07 to 1.21)e
    missing1.17 (0.93 to 1.47)1.03 (0.83 to 1.29)
Phosphorus quintiles (mg/dl)
    ≤4.41.001.00
    4.5 to 5.31.06 (1.00 to 1.13)d1.02 (0.96 to 1.09)
    5.4 to 6.31.13 (1.06 to 1.19)e1.02 (0.96 to 1.08)
    6.4 to 7.51.14 (1.07 to 1.22)e1.10 (1.04 to 1.17)d
    >7.51.25 (1.17 to 1.33)e1.19 (1.12 to 1.27)e
    missing1.13 (0.90 to 1.41)1.19 (0.96 to 1.47)
Calcium × phosphorus product (mg2/dl2)
    ≤40.91.001.00
    41.0 to 50.11.04 (0.98 to 1.11)0.99 (0.94 to 1.06)
    50.2 to 59.21.09 (1.03 to 1.16)d1.05 (0.99 to 1.12)
    59.3 to 71.01.14 (1.07 to 1.22)e1.09 (1.03 to 1.16)d
    >71.01.24 (1.16 to 1.32)e1.19 (1.12 to 1.27)e
    missing1.23 (1.08 to 1.39)d1.12 (0.99 to 1.26)
Parathyroid hormone (pg/dl)
    ≤371.001.00
    38 to 991.03 (0.96 to 1.11)1.06 (0.99 to 1.14)
    100 to 2101.04 (0.97 to 1.12)1.07 (0.99 to 1.15)
    211 to 4801.04 (0.96 to 1.13)1.07 (0.99 to 1.15)
    >4801.12 (1.04 to 1.21)d1.17 (1.08 to 1.26)e
    missing1.06 (0.99 to 1.13)1.12 (1.06 to 1.19)e
  • a Using Cox regression with all of the characteristics shown in the first column of Table 1 entered simultaneously, with the exception of calcium-phosphorus product. Hazards ratios for calcium-phosphorus product were adjusted for all variables except calcium and phosphorus.

  • b Hospitalization for ischemic heart disease, congestive heart failure, stroke, transient ischemic attack, or peripheral vascular disease, or cause of death on the ESRD Death Notification Form attributed to cardiac causes, cerebrovascular accident, or ischemic brain damage.

  • c Denominator <14,829 reflects negative follow-up intervals.

  • d P < 0.05.

  • e P < 0.0001.