Table 6.

Adjusted associations between apo(a) size (K-IV repeats) and CVD events, by adjustment groupa

Adjustment GroupModel (N)CVD Events (N)LMW Apo(a) Size Models Apo(a) ≤ 22 K-IV Repeats versus Apo(a) > 22 K-IV Repeats10th Percentile Apo(a) Size Models Apo(a) ≤ 16 K-IV Repeats versus Apo(a) > 16 K-IV Repeats
HR95% CIPHR95% CIP
Group 1b8332971.40(1.11 to 1.75)0.0041.44(1.01 to 2.06)0.046
Group 2c8322961.42(1.13 to 1.79)0.0031.39(0.96 to 1.99)0.08
Group 3d7312621.58(1.23 to 2.03)<0.00051.68(1.13 to 2.49)0.01
Group 4e6752421.57(1.21 to 2.04)0.0011.90(1.27 to 2.84)0.002
Group 4+CRP6602381.71(1.31 to 2.25)<0.00051.96(1.30 to 2.96)0.001
  • a LMW, low molecular weight.

  • b Adjusted for age, race (black, white, other), gender, and dialysis modality.

  • c Adjusted for group 1 and baseline CVD, comorbidity score, and cause of renal disease.

  • d Adjusted for group 2 and total cholesterol, HDL cholesterol quartile, smoking status, and systolic BP quartile.

  • e Adjusted for group 3 and albumin, creatinine, and body mass index quartiles.