Table 4.

Hazard ratios and confidence intervals from fully adjusted multivariate analysis for primary and secondary outcomes in individuals with CKDa

CompositebCardiacbStrokebMortalityc
Without interaction
    LVH1.67 (1.34 to 2.07)1.62 (1.18 to 2.24)1.78 (1.20 to 2.65)1.74 (1.38 to 2.20)
    anemia1.51 (1.27 to 1.81)1.21 (0.90 to 1.61)1.30 (0.89 to 1.89)1.68 (1.39 to 2.04)
With interaction
    +LVH, +anemia4.15 (2.62 to 6.56)3.92 (2.05 to 7.48)4.24 (2.00 to 8.99)3.30 (2.04 to 5.34)
    +LVH, −anemia1.43 (1.18 to 1.72)1.36 (0.94 to 1.97)1.47 (0.92 to 2.34)1.68 (1.29 to 2.18)
    −LVH, +anemia1.48 (1.16 to 1.89)1.08 (0.79 to 1.48)1.14 (0.75 to 1.71)1.65 (1.35 to 2.02)
    −LVH, −anemiaReferenceReferenceReferenceReference
  • a Cardiac events included recognized and silent myocardial infarction and fatal coronary heart disease. Stroke includes both fatal and nonfatal events. All models were adjusted for age; gender; race; history of CVD, hypertension, and diabetes; current smoking; alcohol use; high school graduation status; systolic BP, total cholesterol; HDL cholesterol; GFR; and study terms.

  • b P < 0.05 for the interaction between anemia and LVH.

  • c The interaction term for anemia and LVH with mortality was not statistically significant (P > 0.20).