Table 1.

Mouse characteristics at age 8 mo

db/+ (n = 10)db/db (n = 10)ICAM-1−/− db/db (n = 10)
Body weight, g37.0 ± 1.555.3 ± 4.3c58.4 ± 1.3c
Blood glucose, mmol/L6.2 ± 0.323.5 ± 3.2c24.9 ± 2.4c
HbA1c, %2.9 ± 0.087.1 ± 0.5c7.0 ± 0.5c
Plasma insulin, ng/ml0.15 ± 0.0470.4 ± 9.4c58.8 ± 14.8c
Plasma cholesterol, mmol/L2.7 ± 0.32.7 ± 0.92.1 ± 0.3
Plasma triglyceride, mmol/L1.0 ± 0.091.7 ± 0.31.2 ± 0.2
  • Data = mean ± standard error.

  • a P < 0.05,

  • b P < 0.01,

  • c P < 0.001 versus db/+ mice.