Table 2.

Kidney leukocytes in experimental mice at age 8 mo

Kidney Leukocytesdb/+ (n = 10)db/db (n = 10)ICAM-1−/− db/db (n = 10)
Glomerular
    CD45 + cells/gcs1.23 ± 0.0512.43 ± 2.2b5.37 ± 1.08d
    CD68 + cells/gcs1.14 ± 0.0312.18 ± 2.4b4.96 ± 1.35c
    CD4 + cells/gcs0.15 ± 0.020.32 ± 0.05a0.15 ± 0.03e
    CD8 + cells/gcs0.01 ± 0.0070.015 ± 0.0010.01 ± 0.007
Interstitial
    CD45 + cells/mm2156.2 ± 6.1432.2 ± 53.3b233.8 ± 19.1e
    CD68 + cells/mm2146.8 ± 5.8397.4 ± 41.6b195.4 ± 9.3e
    CD4 + cells/mm213.0 ± 1.215.8 ± 5.26.8 ± 0.6
    CD8 + cells/mm21.2 ± 0.70.8 ± 0.30.6 ± 0.3
  • Data = mean ± SE.

  • a P < 0.01,

  • b P < 0.001 versus db/+ mice;

  • c P < 0.05,

  • d P < 0.01,

  • e P < 0.001 versus db/db mice.

  • gcs indicates glomerular cross-section.