Table 3.

Ig and complement (C3) deposition in mice developing GNa

Glomerular Ig (AU)Glomerular C3 (AU)
WT C57BL/668 ± 3.450 ± 3.2
IL-12p40−/−91 ± 5.961 ± 5.2
IL-18−/−103 ± 4.8c59 ± 6.6
IL-12p40−/−IL-18−/−96 ± 9.7b53 ± 3.9
  • a Results are expressed as the mean ± SEM of the quantification of Ig deposition by image capture and NIH image analysis of fluorescence from glomeruli (antibody dilution 1:100) for each animal. Numbers of mice studied are WT C57BL/6 (n = 7), IL-12p40−/− (n = 6), IL-18−/− (n = 5), and IL-12p40−/−IL-18−/− (n = 7). GN, glomerulonephritis.

  • b P < 0.05 versus WT C57BL/6 mice (ANOVA).

  • c P < 0.05 versus WT C57BL/6 mice (ANOVA).