Table 4.

Renal function and urinary protein excretion in C57BL/6 WT, IL-12p40−/−, IL-18−/−, and IL-12p40−/−IL-18−/− mice with GNa

Serum Creatinine (μmol/L)Urinary Protein (mg/24 h)Urinary Protein:Creatinine (mg/μmol)
No GN11.1 ± 0.81.2 ± 0.8ND
WT C57BL/6 GN19.4 ± 1.2b7.9 ± 1.13.0 ± 0.6
IL-12p40−/− GN16.1 ± 1.54.8 ± 1.01.3 ± 0.2
IL-18−/− GN18.0 ± 1.8c5.6 ± 1.03.1 ± 0.6
IL-12p40−/−/IL-18−/− GN18.5 ± 0.9c5.1 ± 0.41.9 ± 0.2
  • a Results are expressed as the mean ± SEM. Numbers of mice studied for serum creatinine are No GN (n = 8) WT C57BL/6 (n = 20), IL-12p40−/− (n = 4), IL-18−/− (n = 16), and IL-12p40−/−IL-18−/− (n = 13) and for proteinuria are No GN (n = 13) WT C57BL/6 (n = 19), IL-12p40−/− (n = 5), and IL-18−/− (n = 16), IL-12p40−/−IL-18−/− (n = 13).

  • b P < 0.01 versus No GN.

  • c P < 0.05 versus No GN (ANOVA).