Table 2.

Renal response to gonadectomya

No.SurgeryTreatmentGenotypeGenderNK/B (g/100 g)SUN (mg/dl)
1ShamVehicle+/+M70.70 ± 0.0122.6 ± 0.6
2CastrationVehicle+/+M30.62 ± 0.01 NS24.1 ± 0.2 NS
3CastrationDHT+/+M30.81 ± 0.01b22.0 ± 0.5b
4ShamVehicleCy/+M62.15 ± 0.0438.8 ± 1.1
5CastrationVehicleCy/+M51.35 ± 0.01c28.5 ± 1.8c
6CastrationDHTCy/+M62.12 ± 0.08 NS32.2 ± 1.5b
7ShamVehicle+/+F30.69 ± 0.0222.0 ± 2.0
8OvariectomyVehicle+/+F30.58 ± 0.01 NS22.8 ± 0.3 NS
9OvariectomyDHT+/+F30.85 ± 0.01 NS24.1 ± 0.5 NS
10ShamVehicleCy/+F61.08 ± 0.0224.9 ± 2.3
11OvariectomyVehicleCy/+F51.21 ± 0.03c26.0 ± 1.1 NS
12OvariectomyDHTCy/+F51.67 ± 0.05b25.1 ± 0.8 NS
  • a Age 10 wk. K/B, kidney/body weight; SUN, serum urea nitrogen; DHT, dihydrotestosterone.

  • b 1 versus 3, 4 versus 6, 7 versus 9, 10 versus 12; P < 0.001.

  • c 1 versus 2, 4 versus 5, 7 versus 8, 10 versus 11; P < 0.001.\