Table 3.

Renal protein expressiona

No.SurgeryTreatmentGenotypeGenderARB-RafP-ERKERK
1ShamVehicle+/+M1.0 ± 0.0 (6)1.0 ± 0.0 (4)1.0 ± 0.0 (4)1.0 ± 0.0 (4)
2ShamVehicleCy/+M2.9 ± 0.3 (6)b1.8 ± 0.0 (4)b2.0 ± 0.1 (5)c1.0 ± 0.0 (5) NS
3CastrationVehicle+/+M0.9 ± 0.1 (3)1.1 ± 0.0 (3)1.1 ± 0.1 (3)1.0 ± 0.0 (3)
4CastrationVehicleCy/+M1.1 ± 0.1 (5)d NS1.7 ± 0.1 (3)e NS1.8 ± 0.2 (5)c NS1.0 ± 0.0 (5) NS
5CastrationDHT+/+M1.3 ± 0.2 (6)1.3 ± 0.1 (3)0.9 ± 0.1 (3)0.9 ± 0.0 (3)
6CastrationDHTCy/+M5.3 ± 0.4 (3)bde1.9 ± 0.1 (4)c NS1.8 ± 0.2 (5)b NS0.9 ± 0.0 (5) NS
7ShamVehicle+/+F1.0 ± 0.0 (3)1.0 ± 0.1 (3)1.0 ± 0.1 (3)1.0 ± 0.0 (3)
8ShamVehicleCy/+F1.1 ± 0.1 (6) NS1.7 ± 0.1 (6)b2.1 ± 0.3 (5)b1.0 ± 0.0 (5) NS
9OvariectomyVehicle+/+F1.0 ± 0.1 (3)0.9 ± 0.1 (3)1.5 ± 0.2 (3)0.9 ± 0.0 (3)
10OvariectomyVehicleCy/+F1.1 ± 0.1 (5) NS1.6 ± 0.3 (4)e NS2.0 ± 0.4 (5)c NS0.9 ± 0.0 (5) NS
11OvariectomyDHT+/+F4.7 ± 0.4 (3)1.1 ± 0.1 (3)1.0 ± 0.1 (3)1.0 ± 0.0 (3)
12OvariectomyDHTCy/+F7.4 ± 1.0 (5)cde1.5 ± 0.1 (5)c NS1.6 ± 0.2 (5)c NS0.9 ± 0.0 (5) NS
  • a Data are means ± SE (N). Age 10 wk.

  • b,c+/+ versus Cy/+ in each group:

  • b P < 0.01,

  • c P < 0.05.

  • d Sham vehicle versus castration/ovariectomy vehicle, castration/ovariectomy DHT in Cy/+: P < 0.01.

  • e Castration/ovariectomy vehicle versus DHT: P < 0.01.