Table 4.

Effect of flutamide on kidney weight and SUN in sham-operated ratsa

No.TreatmentGenotypeGenderNK/B (g/100 g)SUN (mg/dl)
1Vehicle+/+M70.70 ± 0.0122.6 ± 0.6
2FLT+/+M30.66 ± 0.02 NS26.3 ± 2.5 NS
3VehicleCy/+M62.15 ± 0.0438.8 ± 1.1
4FLTCy/+M41.71 ± 0.04b33.8 ± 1.3c
5Vehicle+/+F30.69 ± 0.0224.9 ± 2.3
6FLT+/+F40.62 ± 0.01 NS23.0 ± 0.4 NS
7VehicleCy/+F61.08 ± 0.0224.9 ± 2.3
8FLTCy/+F31.14 ± 0.02 NS26.0 ± 1.8 NS
  • a Data are mean ± SE. Age 10 wk. FLT, flutamide.

  • b 1 versus 2, 3 versus 4, 5 versus 6, 7 versus 8; P < 0.01.

  • c 1 versus 2, 3 versus 4, 5 versus 6, 7 versus 8; P < 0.03.\