Table 5.

Effect of flutamide on AR, B-Raf, and ERK

No.TreatmentGenotypeGenderARB-RafP-ERKERK
1Vehicle+/+M1.0 ± 0.0 (6)1.0 ± 0.0 (4)1.0 ± 0.0 (4)1.0 ± 0.0 (4)
2VehicleCy/+M2.9 ± 0.3 (6)b1.8 ± 0.0 (4)b2.0 ± 0.1 (5)b1.0 ± 0.0 (5) NS
3FLT+/+M0.8 ± 0.0 (3)0.8 ± 0.1 (3)0.9 ± 0.1 (3)0.9 ± 0.0 (3)
4FLTCy/+M1.1 ± 0.0 (4)bc1.7 ± 0.1 (4)b NS2.0 ± 0.1 (4)b NS1.0 ± 0.0 (4) NS
5Vehicle+/+F1.0 ± 0.0 (3)1.0 ± 0.1 (3)1.0 ± 0.1 (3)1.0 ± 0.0 (3)
6VehicleCy/+F1.1 ± 0.1 (6) NS1.7 ± 0.1 (6)b2.1 ± 0.3 (5)b1.0 ± 0.0 (5) NS
7FLT+/+F1.0 ± 0.0 (4)1.4 ± 0.2 (4)1.4 ± 0.2 (4)0.9 ± 0.0 (4)
8FLTCy/+F1.0 ± 0.0 (3) NS1.6 ± 0.2 (3) NS1.7 ± 0.4 (3) NS1.0 ± 0.0 (3) NS
  • Data are mean ± SE (N). Age 10 wk.

  • b +/+ versus Cy/+ in each group, P < 0.01.

  • c Cy/+ vehicle versus FLT, P < 0.01.\