Table 1.

Intrarenal chemokine mRNA levels in mice with glomerulonephritisa

WT C57BL/6IL-12p40−/−IL-18−/−IL-12p40−/−/IL-18−/−
CXCL10 (IP-10)75.8 ± 12.083.0 ± 17.493.4 ± 31.356.8 ± 10.6
XCL1 (lymphotactin)2.03 ± 0.442.88 ± 1.221.20 ± 0.321.16 ± 0.37
CCL5 (RANTES)86.4 ± 13.054.6 ± 9.980.4 ± 22.553.6 ± 13.1
CCL1 (TCA-3)7.89 ± 0.997.27 ± 1.047.99 ± 2.155.61 ± 1.16
CCL2 (MCP-1)100.3 ± 11.278.9 ± 16.566.0 ± 19.463.1 ± 8.8
CCL3 (MIP-1α)8.06 ± 1.436.22 ± 0.402.91 ± 0.48c,d3.96 ± 0.56b
CCL4 (MIP-1β)11.6 ± 1.357.53 ± 1.664.12 ± 1.03d5.98 ± 0.96b
CXCL1 (MIP-2)17.0 ± 3.410.5 ± 3.97.73 ± 2.225.27 ± 0.68b
  • a Results are expressed as the means ± SEM (arbitrary units). WT, wild-type mice. Numbers of mice studied are WT C57BL/6 (n = 4), IL-12p40−/− (n = 4), IL-18−/− (n = 5), and IL-12p40−/−IL-18−/− (n = 5).

  • b P < 0.05 versus WT C57BL/6.

  • c P < 0.05 versus IL-12p40−/−.

  • d P < 0.01 versus WT C57BL/6 (ANOVA).