Table 2.

Prevalence and severity of individual symptoms

SymptomPrevalence (%)aMean Severityb
Constipation212.85
Nausea263.16
Vomiting113.5
Diarrhea173.21
Decreased appetite292.52
Muscle cramps433.31
Swelling in legs262.25
Shortness of breath192.90
Lightheadedness or dizziness312.98
Restless legs or difficulty keeping legs still292.79
Numbness or tingling in feet362.64
Feeling tired or lack of energy693.12
Cough292.60
Dry mouth492.97
Bone or joint pain503.61
Chest pain103.63
Headache193.03
Muscle soreness283.14
Difficulty concentrating142.77
Dry skin722.81
Itching543.24
Worrying283.09
Feeling nervous192.90
Trouble falling asleep443.35
Trouble staying asleep433.10
Feeling irritable232.81
Feeling sad202.97
Feeling anxious313.04
Decreased interest in sex363.12
Difficulty becoming sexually aroused343.44
  • a Percentage of patients who reported the symptom.

  • b Based on the five-point Likert scale: 1 = “not at all bothersome” to 5 = “bothers very much.”