Table 2.

Initial and final bone histomorphometry results in patients who were treated with calcium carbonate and sevelamer

Histologic VariableCalcium Carbonate(n = 14)Sevelamer(n = 15)Normal Rangea(n = 31)
InitialbFinalInitialFinal
Bone area (%)28.5 ± 2.329.4 ± 2.831.3 ± 1.528.8 ± 0.914.6 to 26.9
Osteoid area (%)17.8 ± 2.27.2 ± 1.0c15.7 ± 1.811.4 ± 1.3d0.2 to 5.8
Osteoid perimeter (%)53.7 ± 3.032.0 ± 3.6c54.9 ± 3.845 ± 3.0c4.3 to 31.7
Osteoid seam width (μm)22.2 ± 1.016.7 ± 1.2d22.2 ± 1.419.0 ± 0.54.1 to 13.1
Eroded perimeter (%)9.9 ± 0.77.2 ± 0.9d9.5 ± 0.78.4 ± 0.90.4 to 3.4
Double-labeled perimeter (%)21.8 ± 2.09.7 ± 1.4c15.4 ± 2.58.9 ± 1.8d1.6 to 15.8
Trabecular number (n/mm)1.9 ± 0.11.9 ± 0.32.5 ± 0.42.2 ± 0.41.1 to 2.2
Trabecular width (μm)149 ± 11156 ± 11161 ± 8.4161 ± 9.590 to 175
Bone formation rate (μm2/mm2 per d)1782 ± 383568 ± 87c1141 ± 161519 ± 60c93 to 613
  • a Reference values were obtained in 31 children with normal renal function (49).

  • b Initial values did not differ between the two groups.

  • c P < 0.001,

  • d P < 0.05, initial versus final values within each group.