Table 1.

Serum chemistry in control rats, uremic rats, and uremic rats that were treated with the calcimimetic R-568 for the indicated timesa

3 Days7 Days21 Days
NormalUremicNUremicR-568 (4 d)NormalUremicR-568 (14 d)
Creatinine (mg/dl)0.25 ± 0.040.62 ± 0.12b0.27 ± 0.030.60 ± 0.07b0.66 ± 0.130.25 ± 0.021.31 ± 0.2b1.12 ± 0.14
Calcium (mg/dl)10.2 ± 0.329.4 ± 0.14b10.4 ± 0.269.8 ± 0.529.08 ± 0.649.92 ± 0.127.9 ± 0.08b7.0 ± 0.48c
Phosphorus (mg/dl)9.01 ± 0.349.1 ± 1.39.8 ± 0.5110.75 ± 1.9512.96 ± 2.2210.44 ± 1.6215.53 ± 2.61b17.57 ± 1.36
PTH (pg/ml)56 ± 2870 ± 3956 ± 28338 ± 113b29 ± 12c56 ± 28928 ± 142b657 ± 170c
1,25(OH)2D (pg/ml)NDND152 ± 51116 ± 64163 ± 57152 ± 5141.5 ± 29.7bND
PTH mRNA1 ± 0.161.3 ± 0.141 ± 0.171.9 ± 0.05b0.6 ± 0.12c1 ± 0.242.8 ± 0.29b2.3 ± 0.2c
n55444554
  • a PTH mRNA levels are corrected for 18S RNA and expressed as percentage of normal rats. PTH, parathyroid hormone; ND, not done.

  • b P < 0.05, for the uremic rats versus the rats that were fed a control diet (normal).

  • c P < 0.05, for the uremic rats that were given R-568 versus the uremic rats. The results are from a representative experiment using the number of rats as shown in this experiment.\