Table 1.

Comparison of PKD1 versus PKD2 imaging/clinical parametersa

VariablePKD1 (n = 185)PKD2 (n = 34)Pb
Baseline values
    hypertension120 (65%)17 (50%)0.0998
0.0205
    mean age (yr)31.7735.420.0281
31.7435.400.028
    mean kidney volume (ml)1010.90688.11<0.0001
1040.85622.56<0.0001
    mean cyst volume (ml)384.03199.260.0011
397.56171.60<0.0001
    mean GFR (ml/min per 1.73 m2)96.9296.670.96
95.9799.710.39
    mean 24-h urinary albumin (g/L)27.9416.590.0108
28.3516.310.0078
    mean number of cystsc30.7918.76<0.0001
31.4717.03<0.0001
    total RBFd (ml/min per 1.73 m2;731.1731.020.9264
    PKD1 n = 85; PKD2 n = 15)734.75752.340.7681
Changes per yeare(n = 179)(n = 33)
    GFR (ml/min)−1.11−0.890.89
0.910.320.72
    kidney volume change (ml)71.3834.800.0055
74.9432.2170.001
    rate of kidney volume change (%)5.554.690.24
5.684.820.24
    cyst volume change (ml)70.6928.720.0015
74.6124.980.0001
    rate of cyst volume change (%)12.2111.400.58
12.4612.080.79
  • a Values adjusted for age, gender, and the age and gender interaction (except for mean age, adjusted for gender only) are shown in italics. PKD, polycystic kidney disease; RBF, renal blood flow.

  • b Significant P values are in boldface.

  • c Measured from representative magnetic resonance imaging (MRI) section (see Materials and Methods for details).

  • d RBF was available only on a subset of cases.

  • e Mean calculated over 3 yr of follow-up.