Table 1.

Baseline characteristics of the db/m and db/db mice after 8 wk of treatment with SU5416 or vehicle

MiceBody Weight (g)Total Kidney Weight (g)Heart Weight (g)Plasma Glucose (mg/dl)
db/m control (n = 12)29.7 ± 0.30.41 ± 0.010.15 ± 0.00143 ± 13
db/m SU5416 (n = 12)27.9 ± 0.40.40 ± 0.000.15 ± 0.01152 ± 9
db/db control (n = 10)46.3 ± 1.7a0.43 ± 0.01a0.13 ± 0.00506 ± 39a
db/db SU5416 (n = 10)48.4 ± 8.0a0.40 ± 0.03b0.15 ± 0.03416 ± 41a
  • a P < 0.05 versus nondiabetic db/m control.

  • b P < 0.05 versus diabetic db/db control.