Table 1.

Measurement of [Ca2+]i in cells derived from cystic and noncystic regions of the same ADPKD kidneysa

Kidney No.Noncystic CellsCystic CellsΔ[Ca2+]i
K233 (n = 15 monolayers)62.5 ± 1.0 nM40.6 ± 0.6 nMb21.9 nM
K229 (n = 9 monolayers)72.8 ± 3.0 nM49.7 ± 2.9 nMb23.1 nM
  • a [Ca2+]i were determined in subconfluent monolayers of epithelial cells that were cultured from either noncystic or cystic regions of early-stage autosomal dominant polycystic kidney disease (ADPKD) kidneys. These kidneys were removed from patients with relatively normal renal function as a result of pain. Values are means ± SEM for Ca2+ concentrations determined at five random locations on each monolayer.

  • b P < 0.001 versus the noncystic cells.