Table 3.

Inflammation, neoangiogenesis, and fibrosis in WT and RAGE −/− mice

WT Mice (n = 8 per Group)RAGE −/− Mice (n = 8 per Group)
Inflammatory Cell NumberNo. of Vessels/AreaFibrosis ScoreInflammatory Cell NumberNo. of Vessels/AreaFibrosis Score
Sham13.0 ± 2.17a5.69 ± 0.69a0.67 ± 0.4120.1 ± 2.2214.0 ± 3.060.67 ± 0.82
Sham i.p.18.0 ± 4.088.61 ± 1.380.67 ± 0.8221.5 ± 4.5613.4 ± 2.160.67 ± 0.82
Filter-sterilized19.2 ± 3.7910.9 ± 3.251.17 ± 0.9826.8 ± 2.0614.0 ± 1.441.00 ± 0.89
Glucose-free22.1 ± 4.6311.1 ± 1.58a1 ± 0.8224.9 ± 4.614.1 ± 2.711.00 ± 1.26
Low GDP20.2 ± 4.1911.4 ± 1.59a1.00 ± 1.2624.9 ± 6.8216.3 ± 3.471.17 ± 0.75
High GDP23.5 ± 2.73a12.4 ± 2.18a2 ± 0.89a25.9 ± 6.0114.5 ± 2.471.5 ± 0.84
  • a P < 0.05 versus sham i.p.