Table 2.

Changes in Hct, Hb, plasma albumin, ECF, TBW, and body weight in 260 patients with type 2 diabetes after 12 wk of treatment with RSG 4 mg twice daily in addition to background sulfonylurea or sulfonylurea plus metformin therapya

VariableBaselineEnd of Chronic RSG TreatmentAbsolute ChangeP
Hct (%)42.1 ± 3.639.2 ± 4.0−2.92 (−3.10 to −2.63)<0.001
Hb (g/dl)14.1 ± 1.213.0 ± 1.4−1.03 (−1.09 to −0.93)<0.001
Plasma albumin (g/L)45.0 ± 2.444.6 ± 2.6−0.46 (−0.77 to −0.22)<0.001
ECF (L/1.73 m2)16.9 ± 2.517.5 ± 2.40.62 (0.26 to 0.90)<0.001
TBW (L/1.73 m2)38.7 ± 4.439.5 ± 4.20.79 (0.52 to 1.08)<0.001
Body weight (kg)84.7 ± 16.786.5 ± 17.01.78 (1.51 to 2.06)<0.001
  • a Data are means ± SD or means (95% CI) absolute change. CI, confidence interval; ECF, extracellular fluid; Hb, hemoglobin; Hct, hematocrit; TBW, total body water.