Table 2.

Hemoglobin quintiles and CHD-related deaths, by different methods of estimating GFRa

Hemoglobin QuintileMethod of Estimating GFRCKD (GFR <60 ml/min per 1.73 m2)No CKD (GFR 60 ml/min per 1.73 m2)
No. at RiskNo. of DeathsRatebMultivariate-Adjusted HR (95% CI)cNo. at RiskNo. of DeathsRatebMultivariate-Adjusted HR (95% CI)cP Interactiond
Lowest quintileCockcroft-3526425.01.49 (1.08 to 2.06)25841.80.55 (0.18 to 1.62)0.05
Other quintiles    Gaultf128711511.2Reference1177414.0Reference
Lowest quintileAbbreviated3125323.11.36 (0.95 to 1.94)298156.11.21 (0.66 to 2.20)0.61
Other quintilesMDRD11159510.5Reference1349615.3Reference
Lowest quintileBjornssonf2996329.91.57 (1.12 to 2.19)31151.90.51 (0.20 to 1.31)0.08
Other quintiles95910213.6Reference1505544.1Reference
High SCreLow SCre
Lowest quintileSerum992847.31.80 (1.02 to 3.18)511409.61.09 (0.75 to 1.58)0.04
Other quintilesCreatinine (SCr)1953121.8Reference22691256.5Reference
  • a MDRD, Modification of Diet in Renal Disease; SCr, serum creatinine; HR, hazard ratio; CI, confidence interval.

  • b Rate per 1000 person-years of follow-up.

  • c Cox regression model adjusting for age, gender, pre-existing CHD, smoking status, alcohol consumption, mean arterial BP, total cholesterol and fibrinogen levels, body mass index, diabetes, and self-reported health status.

  • d P value for interaction terms GFR × hemoglobin (or SCr × hemoglobin) in the multivariate adjusted model. GFR, SCr, and hemoglobin are treated as continuous variables for assessing interaction.

  • e High SCr is SCr ≥ 1.46 mg/dl (for men) and SCr ≥ 1.26 mg/dl (for women); low SCr is SCr < 1.46 mg/dl (for men) and SCr < 1.26 mg/dl (for women).

  • f Corrected for body surface area.