Effect of iv iron saccharate and α-darbepoetin treatments on erythrocyte redox statusa
| Erythrocyte Concentration (μmol/g Hb) | Baseline | Intravenous Iron | α-Darbepoetin | P |
|---|---|---|---|---|
| MDA | 1.8 ± 0.1 | 3.2 ± 0.6b | 2.2 ± 0.1 | <0.05 |
| GSSG | 0.9 ± 0.1 | 1.5 ± 0.2 | 1.1 ± 0.2 | NS |
| GSH | 4.8 ± 0.8 | 3.3 ± 0.73 | 8.8 ± 1.8c | <0.01 |
| GSH/GSSG | 4.9 (25.5) | 2.07 (2.18) | 9.96 (41.1) | <0.05d |
| GPx | 28.8 ± 2.3 | 41.6 ± 9.5e | 17.5 ± 4.5 | <0.05 |
| GRed | 2.6 ± 0.3 | 5.2 ± 1.1 | 3.6 ± 0.4 | NS |
↵a Data are means ± SD or median (interquartile range) as appropriate. GSH, reduced glutathione; GPx, glutathione peroxidase; GRed, glutathione reductase; GSSG, oxidized glutathione; Hb, hemoglobin; MDA, malondialdehyde.
↵b P < 0.05 baseline versus intravenous iron.
↵c P < 0.05 intravenous iron versus α-darbepoetin.
↵d Kruskal-Wallis test was performed because values were not followed a normal distribution.
↵e P < 0.05 baseline versus intravenous iron.