Table 1.

Effect of iv iron saccharate and α-darbepoetin treatments on erythrocyte redox statusa

Erythrocyte Concentration (μmol/g Hb)BaselineIntravenous Ironα-DarbepoetinP
MDA1.8 ± 0.13.2 ± 0.6b2.2 ± 0.1<0.05
GSSG0.9 ± 0.11.5 ± 0.21.1 ± 0.2NS
GSH4.8 ± 0.83.3 ± 0.738.8 ± 1.8c<0.01
GSH/GSSG4.9 (25.5)2.07 (2.18)9.96 (41.1)<0.05d
GPx28.8 ± 2.341.6 ± 9.5e17.5 ± 4.5<0.05
GRed2.6 ± 0.35.2 ± 1.13.6 ± 0.4NS
  • a Data are means ± SD or median (interquartile range) as appropriate. GSH, reduced glutathione; GPx, glutathione peroxidase; GRed, glutathione reductase; GSSG, oxidized glutathione; Hb, hemoglobin; MDA, malondialdehyde.

  • b P < 0.05 baseline versus intravenous iron.

  • c P < 0.05 intravenous iron versus α-darbepoetin.

  • d Kruskal-Wallis test was performed because values were not followed a normal distribution.

  • e P < 0.05 baseline versus intravenous iron.