Table 1.

Heptahelical receptors that may modulate TRPC6 function in podocytesa

ReceptorKmBmaxbEffector PathwayReferences
Ang II
    AT1≈3.0 nM≈562 fmol/mgcAMP, calcium, IP3(4246)
    AT2≈3.0 nM≈196 fmol/mgcAMP, calcium(4245)
Prostaglandin
    EP1NDNDCalcium(47)
    EP4NDNDcAMP(47)
    FPNDNDCalcium(47)
    TPNDNDCalcium(47)
Endothelin
    ET1≈0.4 nM≈8.1 × 1010 sites/mgCalcium, IP3(48,49)
Leukotrienes
    LTC4≈217 nM≈4.5 pmol/mgCell proliferation(50)
    LTD4ND†NDCell proliferation, PKC(51)
Bradykinin
    BK2≈0.04 nM≈77 fmol/mgCalcium, IP3(52,53)
ATP
    P2y2NDNDCalcium, IP3(54)
Histamine
    H1NDNDCalcium, IP3(55)
Adrenergic
    α1NDNDCalcium(56)
    β4NDNDcAMP(56)
ThrombinNDNDCalcium, IP3(57)
Dopamine
    D1NDNDcAMP(58)
    PTHNDNDcAMP(59,60)
Chemokines
    CCR4, 8, 9, 10NDNDcAMP(61)
    CXCR1, 3, 4, 5NDNDCalcium(61)
  • a Ang II, angiotensin II; AT1, type 1 Ang II receptor; AT2, type 2 Ang II receptor; ≈, approximately; IP3, inositol 1,4,5 triphosphate; ND, not done; PKC, protein kinase C; PTH, parathyroid hormone.

  • b fmol or sites/mg protein.