Table 1.

Baseline characteristics of nondiabetic lean Zucker rats and ZDF rats

NondiabeticDiabetic
Body weight (g)369 ± 7 (n = 11)398 ± 13b (n = 10)
Weight of the two kidneys2.6 ± 0.1 (n = 11)3.6 ± 0.1b (n = 10)
Blood glucose concentration (mM)8.4 ± 0.3 (n = 11)28.3 ± 1.0b (n = 10)
Blood pH7.38 ± 0.02 (n = 4)7.37 ± 0.02 (n = 4)
Plasma bicarbonate (mM)26.3 ± 1.2 (n = 4)25.4 ± 1.9 (n = 4)
Blood β-hydroxybutyrate concentration (mM)0.17 ± 0.01 (n = 4)0.37 ± 0.20b (n = 4)
Blood acetoacetate concentration (mM)0.11 ± 0.01 (n = 4)0.32 ± 0.11b (n = 4)
Plasma cAMP concentration (nM)10 ± 2 (n = 6)18 ± 2b (n = 6)
Plasma corticosterone concentration (ng/ml)368 ± 44 (n = 5)674 ± 69b (n = 5)
  • aValues are means ± SEM. for the number (n) of rats shown in parentheses. ZDF, Zucker Diabetic Fatty.

  • b P < 0.05 nondiabetic versus diabetic, unpaired t test.\