Table 2.

Association between baseline predictors and lowest quintile (n = 47) renal function slope by different methods (95% CI)a

Baseline PredictorsOdds Ratiob by Renal Function Method
Unstandardized Iothalamate Clearance Slope <−7.1%/yrStandardized Iothalamate Clearance Slope <−8.0%/yr1/SCr Slope <−6.7%/yrMDRD Equation Slope <−8.3%/yrCockcroft- Gault Equation Slope <−6.9%/yrCreatinine Clearance Slope <−7.0%/yr
Hypertension5.8(2.3to14)c5.8(2.3to14)c2.0(1.0to4.2)2.0(1.0to4.2)1.9(0.9to3.9)2.0(1.0to4.2)
Kidney volume per doubling2.4(1.5to3.7)c2.3(1.5to3.5)c1.7(1.1to2.6)c1.7(1.1to2.5)c2.1(1.4to3.3)c1.7(1.1to2.5)c
Cyst volume per doubling1.6(1.2to2.0)c1.5(1.2to1.9)c1.3(1.0to1.7)c1.3(1.0to1.7)c1.4(1.1to1.7)c1.3(1.0to1.6)c
Urine ACR per doubling1.3(1.0to1.6)c1.3(1.1to1.7)c1.3(1.0to1.6)c1.3(1.0to1.7)c1.1(0.9to1.4)1.0(0.8to1.3)
History of UTI2.2(1.2to4.3)c1.8(0.9to3.4)0.9(0.5to1.8)1.0(0.5to2.0)1.0(0.5to1.8)1.3(0.6to2.4)
Abdominal pain1.7(0.9to3.4)1.2(0.6to2.3)1.7(0.9to3.5)1.7(0.9to3.5)2.0(1.0to4.0)2.2(1.0to4.5)c
Gross hematuria1.6(0.8to3.1)1.6(0.8to3.2)1.2(0.6to2.5)1.4(0.7to2.8)1.0(0.5to2.0)1.2(0.6to2.5)
Current smoker1.8(0.8to4.0)1.8(0.9to3.4)0.9(0.2to4.0)1.1(0.5to2.6)1.5(0.5to2.6)1.8(0.8to4.1)
Age group per 10 yr1.5(1.0to2.1)1.3(0.9to1.9)1.1(0.7to1.5)0.9(0.6to1.4)1.3(0.9to1.9)1.4(0.9to2.0)
Female1.8(0.9to3.7)1.6(0.8to3.2)0.7(0.3to1.3)0.7(0.4to1.4)0.6(0.3to1.2)0.7(0.4to1.4)
Black1.1(0.4to3.4)1.1(0.4to3.4)1.7(0.6to4.8)1.7(0.6to4.8)1.8(0.6to5.8)1.6(0.6to4.2)
  • a CI, confidence interval; UTI, urinary tract infection.

  • b Odds ratios adjusted for study site. Results were similar when limited to patients who completed all four visits(n = 192).

  • c Statistically significant(P < 0.05, Wald test).\