Table 3.

Association between baseline predictors and renal function slope by different methodsa

Baseline PredictorsUnstandardized Iothalamate Clearance (ml/min)Standardized Iothalamate Clearance (ml/min per 1.73 m2)1/SCrMDRD EquationCockcroft-Gault EquationCreatinine Clearance
Nominal predictors (t test)
    hypertensive−3.1%/y−3.3%/y−2.5%/y−3.5%/y−2.6%/y−1.3%/y
    normotensive1.0%/y0.3%/y−1.2%/y−2.1%/y−0.7%/y0.6%/y
(P < 0.001)(P = 0.003)(P = 0.08)(P = 0.11)(P = 0.02)(P = 0.25)
    UTI history−2.5%/y−3.0%/y−1.8%/y−2.7%/y−1.7%/y−0.8%/y
    no UTI history−0.7%/y−1.1%/y−2.2%/y−3.2%/y−2.0%/y−0.7%/y
(P = 0.11)(P = 0.11)(P = 0.67)(P = 0.61)(P = 0.80)(P = 0.95)
    abdominal pain−2.2%/y−2.4%/y−2.4%/y−3.4%/y−2.4%/y−2.5%/y
    no abdominal pain−0.5%/y−1.2%/y−1.4%/y−2.3%/y−1.0%/y2.4%/y
(P = 0.16)(P = 0.33)(P = 0.21)(P = 0.24)(P = 0.11)(P = 0.003)
    gross hematuria−1.8%/y−2.2%/y−2.3%/y−3.3%/y−2.2%/y−1.2%/y
    no hematuria−1.4%/y−1.8%/y−1.9%/y−2.8%/y−1.7%/y−0.3%/y
(P = 0.80)(P = 0.75)(P = 0.56)(P = 0.60)(P = 0.61)(P = 0.61)
    current smoker−3.3%/y−3.6%/y−2.0%/y−3.0%/y−2.2%/y−3.1%/y
    nonsmoker−1.2%/y−1.6%/y−2.0%/y−2.9%/y−1.8%/y0.0%/y
(P = 0.18)(P = 0.21)(P = 0.98)(P = 0.89)(P = 0.72)(P = 0.16)
    female−2.3%/y−2.8%/y−1.7%/y−2.6%/y−1.3%/y−0.8%/y
    male−0.4%/y−0.7%/y−2.4%/y−3.4%/y−2.7%/y−0.2%/y
(P = 0.10)(P = 0.10)(P = 0.38)(P = 0.35)(P = 0.11)(P = 0.70)
    black−0.7%/y−1.5%/y−2.1%/y−3.0%/y−1.8%/y−2.7%/y
    white−1.6%/y−2.0%/y−2.0%/y−2.9%/y−1.8%/y−0.3%/y
(P = 0.63)(P = 0.81)(P = 0.93)(P = 0.94)(P = 0.99)(P = 0.38)
Continuous predictors (Pearson correlation with logarithmic renal function slope)
    kidney volume (logarithmic)r = −0.33(P < 0.001)r = −0.30(P < 0.001)r = −0.25(P < 0.001)r = −0.23(P < 0.001)r = −0.28(P < 0.001)r = −0.19(P = 0.003)
    cyst volume (logarithmic)r = −0.28(P < 0.001)r = −0.26(P < 0.001)r = −0.21(P = 0.001)r = −0.19(P = 0.004)r = −0.24(P < 0.001)r = −0.20(P = 0.002)
    urine ACR (logarithmic)r = −0.19(P = 0.004)r = −0.21(P = 0.002)r = −0.17(P = 0.01)r = −0.16(P = 0.02)r = −0.08(P = 0.26)r = −0.14(P = 0.04)
    ager = −0.10(P = 0.14)r = −0.06(P = 0.39)r = −0.08(P = 0.23)r = −0.04(P = 0.55)r = −0.17(P = 0.01)r = −0.15(P = 0.02)
  • a ACR, albumin to creatinine ratio.