Table 1.

Baseline calcium and flow-induced calcium peaka

MouseHuman
Pkd1+/+(n = 6)Pkd1+/null(n = 6)Pkd1null/null(n = 8)RCTE(n = 6)9-12(n = 6)NK(n = 8)NT(n = 7)CysT(n = 12)
Baseline calcium (nM)132 ± 11137 ± 14142 ± 8119 ± 7124 ± 10104 ± 5106 ± 8110 ± 5
Calcium peak (nM)377 ± 36399 ± 50149 ± 8350 ± 64128 ± 8268 ± 62266 ± 47115 ± 5
  • a ADPKD, autosomal dominant polycystic kidney disease; CysT, cystic tubules from ADPKD kidneys; NK, normal kidney; NT, normal-looking tubules of ADPKD kidneys; RCTE, renal cortical tubular epithelia; 9-12, ADPKD cyst-lining epithelia. n denotes the number of monolayers. Fifty cells from each monolayer were randomly chosen for analysis.