Table 3.

Hazard ratio of death for hemoglobin categories based on time-dependent Cox regression modelsa

UnadjustedCase Mix–AdjustedCase Mix–and MICS-Adjusted
HR (95% CI)PHR (95% CI)PHR (95% CI)P
All-cause death hemoglobin range (g/dl)
<9.04.89 (4.48 to 5.34)<0.0013.08 (2.81 to 3.37)<0.0011.81 (1.65 to 1.99)<0.001
9.0 to <9.53.58 (3.23 to 3.95)<0.0012.46 (2.22 to 2.73)<0.0011.58 (1.43 to 1.76)<0.001
9.5 to <103.08 (2.82 to 3.36)<0.0012.19 (2.00 to 2.39)<0.0011.50 (1.37 to 1.64)<0.001
10.0 to <10.52.64 (2.45 to 2.86)<0.0012.05 (1.89 to 2.21)<0.0011.48 (1.37 to 1.61)<0.001
10.5 to <112.01 (1.88 to 2.16)<0.0011.67 (1.56 to 1.80)<0.0011.34 (1.25 to 1.44)<0.001
11.0 to <11.51.35 (1.26 to 1.45)<0.0011.22 (1.14 to 1.31)<0.0011.12 (1.05 to 1.20)0.001
11.5 to <121NA1NA1NA
12.0 to <12.50.87 (0.81 to 0.93)<0.0010.91 (0.85 to 0.97)0.0040.94 (0.88 to 1.01)0.07
12.5 to <130.86 (0.80 to 0.92)<0.0010.90 (0.83 to 0.96)0.0020.92 (0.85 to 0.98)0.02
13.0 to <13.50.97 (0.89 to 1.05)0.41.00 (0.92 to 1.08)0.91.04 (0.96 to 1.13)0.4
13.5 to <141.17 (1.06 to 1.29)0.0021.21 (1.10 to 1.33)<0.0011.24 (1.12 to 1.37)<0.001
≥14.01.25 (1.13 to 1.38)<0.0011.15 (1.04 to 1.28)0.0061.17 (1.06 to 1.30)0.002
CV death hemoglobin range (g/dl)
<9.03.83 (3.30 to 4.44)<0.0012.49 (2.14 to 2.90)<0.0011.66 (1.41 to 1.94)<0.001
9.0 to <9.53.39 (2.90 to 3.97)<0.0012.43 (2.07 to 2.85)<0.0011.71 (1.45 to 2.01)<0.001
9.5 to <102.66 (2.31 to 3.06)<0.0011.91 (1.66 to 2.20)<0.0011.42 (1.23 to 1.63)<0.001
10.0 to <10.52.51 (2.23 to 2.83)<0.0012.00 (1.77 to 2.25)<0.0011.54 (1.36 to 1.74)<0.001
10.5 to <111.88 (1.69 to 2.09)<0.0011.60 (1.43 to 1.78)<0.0011.33 (1.19 to 1.49)<0.001
11.0 to <11.51.43 (1.29 to 1.58)<0.0011.29 (1.17 to 1.43)<0.0011.21 (1.09 to 1.34)<0.001
11.5 to <121NA1NA1NA
12.0 to <12.50.90 (0.81 to 1.00)0.040.94 (0.85 to 1.04)0.250.96 (0.87 to 1.06)0.4
12.5 to <130.93 (0.84 to 1.03)0.170.96 (0.87 to 1.07)0.50.96 (0.87 to 1.07)0.5
13.0 to <13.51.04 (0.92 to 1.17)0.51.06 (0.94 to 1.20)0.31.08 (0.96 to 1.21)0.22
13.5 to <141.18 (1.02 to 1.36)0.031.22 (1.05 to 1.41)0.0091.21 (1.04 to 1.40)0.01
≥14.01.23 (1.06 to 1.43)0.0061.15 (0.99 to 1.34)0.071.14 (0.97 to 1.33)0.11
  • a CI, confidence interval; CV, cardiovascular; HR, hazard ratio; MICS, malnutrition-inflammation complex syndrome.