Table 2.

Serum markers at 8 h after injection of calcitriol in wild-type and Gcm2 null micea

Vehicle (n = 6)Calcitriol (n = 6)P
Wild-type
    FGF23 (pg/ml)113.5 ± 6.2213.8 ± 14.60.0000
    PTH (pg/ml)37.6 ± 7.619.1 ± 1.80.0413
    phosphate (mg/dl)10.5 ± 0.510.4 ± 0.20.8691
    calcium (mg/dl)8.2 ± 0.28.4 ± 0.10.6536
Gcm2 null
    FGF23 (pg/ml)40.8 ± 6.1212.4 ± 52.00.0083
    PTH (pg/ml)13.7 ± 0.514.8 ± 0.90.2744
    phosphate (mg/dl)13.0 ± 0.614.9 ± 1.10.1631
    calcium (mg/dl)4.6 ± 0.45.6 ± 0.40.1051
  • a Data shown are serum markers from 8-wk-old C57BL/6 mice and 8- to 12-wk-old Gcm2 null mice, which received intraperitoneal injections of vehicle or 100 ng/kg body wt calcitriol. Data were collected at 8 h after injection of vehicle or calcitriol. Data are expressed as mean ± SEM. The statistically significant difference was set at P < 0.05 by t test analysis. FGF23, fibroblast growth factor 23; PTH, parathyroid hormone.