Table 4.

Number of men with ESRD in MRFIT by proteinuria, eGFR, and hematocrit levels at baseline and summary of Cox regression analysisa

Labstix ResultNo. of MenNo. with ESRDCox Regression Summary (HR [95% CI])
UnadjustedAdjustedbAdjustedc
Negative/trace12380173 (1.4%)1.00 (referent)1.00 (referent)1.00 (referent)
    1+33514 (4.2%)3.10 (1.78 to 5.42)2.31 (1.29 to 4.15)2.30 (1.28 to 4.13)
    2+ or higher13926 (18.7%)15.70 (10.33 to 23.87)15.15 (9.83 to 23.37)14.21 (9.16 to 22.05)
GFR (ml/min per 1.73 m2)
    ≥758241122 (1.5%)1.00 (referent)1.00 (referent)1.00 (referent)
    60 to 75412863 (1.5%)1.03 (0.76 to 1.39)0.91 (0.66 to 1.27)0.89 (0.64 to 1.24)
    <6049728 (5.6%)3.85 (2.55 to 5.82)3.09 (1.97 to 4.82)2.41 (1.52 to 3.82)
    β (SE)−0.020 ± 0.006−0.020 ± 0.006−0.015 ± 0.006
    P value<0.0010.0010.014
Creatinine (mg/dl)
    <1.0170620 (1.2%)1.00 (referent)1.00 (referent)1.00 (referent)
    1.0 to 1.29344141 (1.5%)1.17 (0.73 to 1.86)1.18 (0.72 to 1.93)1.18 (0.72 to 1.95)
    1.3 to 1.4160329 (1.8%)1.40 (0.79 to 2.48)1.29 (0.70 to 2.37)1.29 (0.70 to 2.37)
    ≥1.521323 (10.8%)8.99 (4.91 to 16.47)7.10 (3.71 to 13.58)4.28 (2.15 to 8.52)
    β (SE)2.330 ± 0.4201.964 ± 0.4431.314 ± 0.426
    P value<0.001<0.0010.002
Hematocrit (%)
    <42104320 (1.9%)1.16 (0.72 to 1.86)1.03 (0.64 to 1.67)0.97 (0.59 to 1.58)
    42 to 5411550188 (1.6%)1.00 (referent)1.00 (referent)1.00 (referent)
    ≥552644 (1.5%)0.94 (0.35 to 2.56)0.96 (0.35 to 2.62)0.90 (0.33 to 2.46)
    β (SE)−0.001 ± 0.002−0.001 ± 0.002−0.001 ± 0.002
    P value0.6690.7790.784
  • a Values are for analyses using those variables as continuous measures. P values associated with β coefficients are from Wald tests.

  • b Included in model are age, race (black/nonblack), plasma triglycerides, LDL cholesterol, HDL cholesterol, smoking status (yes/no), family history of diabetes (yes/no), serum glucose and uric acid, BMI, and baseline systolic BP.

  • c All variables in b plus proteinuria, eGFR, and hematocrit.